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. 2018 Jan 20;5(2):226–235. doi: 10.1002/acn3.505

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A model of human midbrain organoids. (A) Developing (day 35) human midbrain organoids contained multiple polarized neuroepithelia. Apical side is marked by aPKC (red), basal side is enriched with neuronal cells marked by MAP2 (green). Note that the green‐orange color staining lining the exterior of the organoid is due to nonspecific staining of Matrigel. Scale bar: 500 um. (B) Long‐term cultures of human midbrain organoids accumulate neuromelanin (black spots).