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. 2017 Dec 19;5(2):147–161. doi: 10.1002/acn3.513

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Kv1.3 inhibition with PAP‐1 reduces infarction and improves neurological deficit in rats. (A) Fluorescent staining for Kv1.3 and iNOS in the border zone of an ischemic infarct from a rat, which contains many ED1 (= CD68) positive microglia/macrophages. (B) Infarct area in brain slices 2, 4, 6, 8, 10, 12 and 16 mm from the frontal pole in vehicle‐treated rats or rats treated with 40 mg/kg PAP‐1 twice daily started 12 h after reperfusion. (C) Neurological deficit in the 14‐score system (normal rat = 14). Values are mean ± S.E.M.