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Effect of α chain length on the ability of pyrrolidinophenones to inhibit synaptosomal reuptake at DAT and SERT (Kolanos et al., 2015a).
| |||
|---|---|---|---|
| R | IC50 (nM) | ||
|
| |||
| DAT | SERT | ||
| α-PHP | -CH2CH2CH2CH3 | 11.6 | >10,000 |
| α-PVP | -CH2CH2CH3 | 17.5 | >10,000 |
| α-PBP | -CH2CH3 | 63.3 | >10,000 |
| α-PPP | -CH3 | 196.7 | >10,000 |
| -H | 3,250 | >10,000 | |
