Table 3.

Behavioral and toxic effects of MDPV and MDPV analogs compared to racemic amphetamine (Benzedrine^®). Data obtained and adapted from patents related to MDPV (FR 5502, GB 1,149,366 and DE 1,545,591).

a MDPV α-alkyl group	Za–c	LD50d	Je
n-Propyl (i.e. MDPV)	0.20	175	875
isoPropyl	0.96	285	296
n-Butyl	0.54	250	463
f Benzedrine	1.95	80	42

^aDoses refer to base dose.

^bZ = dose required for stimulation of the central nervous system mg/kg (mouse, s.c.).

^cIt is unclear if value represents minimal effective dose (MED), effective dose 50% (ED₅₀), or other representative score.

^dLD₅₀ = lethal dose 50%, toxicity in mg/kg (mouse) s.c.

^eJ = (potential) therapeutic index = LD₅₀/Z.

^fBenzedrine^® [(±)-amphetamine] was used as reference CNS stimulant.