Table 4.

Examples of Daptomycin Resistance Mutations Identified in Different Species from Experimental Evolution

species	daptomycin resistance mutation	references
Enterococcus faecalis	signaling: mutations upregulating LiaFSR signaling	Miller et al.21 Arias et al.51
	membrane lipid remodeling: mutations in cls	Davlieva et al.54
Staphylococcus aureus	membrane lipid remodeling: mutations in mprF	Friedman et al.55
Bacillus subtilis	signaling: mutations upregulating VraRS signaling	Hachmann et al.52
	membrane lipid remodeling: mutations in pgsA	Hachmann et al.53