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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Stem Cells. 2016 Nov 2;35(3):777–786. doi: 10.1002/stem.2523

Figure 7. Activation of NIK alters the expression of genes regulating HSPC homeostasis, lineage commitment, and inflammatory responses.

Figure 7

(A, C) RNA-seq analyses of sorted KLS cells from 5-day-old WT or caNIK mice. Heat maps were generated from selected genes of interest. Genes with * are significantly up- or down-regulated. (B, E) Gene set enrichment analysis (GSEA) of statistically significant gene sets enriched in the KLS cells of caNIK mice (up in caNIK) or WT mice (down in caNIK). (D) Selected relative expression of genes that are important for HSPC homeostasis from RNAseq analysis (**p<0.01).