Table 1.

Clinical studies that investigated incidence of Alzheimer’s disease in patients with atrial fibrillation

Literature	Study	Subjects	Follow-up	Dementia	Results
Ott [6]	Rotterdam study	6,584 subjects, 59.2% female, average 69 years	Cross-sectional study	206 AD (75%), 41 VaD, 29 other cause, 1 unknown	Age- and sex-adjusted odds ratio:
					AD with CVD, 4.1 (1.7–9.7)
					AD without CVD, 1.8 (1.0–3.3)
					VaD, 1.9 (0.6–5.5)
Rusanen [5]	Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study	1510 subjects, 62% female, mean 65 years	Longitudinal study for 7.8 years	127 dementia (8.4%), including 102 AD	Hazard ratio:
					All-cause dementia, 2.61 (1.05–6.47)
					AD, 2.54 (1.04–6.16)
Dublin [7]	Adult Changes in Thought (ACT) study	3045 subjects, 60% female, mean 74 years	Longitudinal study for 6.8 years	572 dementia, including 449 AD	Adjusted odds ratio:
					All-cause dementia, 1.38 (95% CI 1.10–1.73)
					AD, 1.50 (95% CI 1.16–1.94)
Bunch [9]	Intermountain Heart Collaborative study	37,025 subjects, 39.9% female, average 60.6 years	Longitudinal study 5 years	1535 dementia (347 AD, 179 VaD)	Odds ratio:
					All-cause dementia, 1.73
					AD, 1.06
					AD (70 years or older), 2.30
Di Nisio [10]	Study in Geriatric Clinic (Chieti, Italy)	784 subjects, 59.2% female, average 77.5 years	Cross-sectional study	309 dementia (44 VaD, 73 AD, 50 AD with CVD, 81 other causes, 61 non-dementia)	Hazard ratio:
					AD, 1.72
					VaD, 2.0
Marengoni [11]	Kungsholmen project	685 subjects, 78 years or older at baseline	Longitudinal for 6 years	170 dementia (143 AD)	Hazard ratio:
					All-cause dementia, 0.9 (95% CI, 0.5–1.7)
					AD, 0.8 (95% CI, 0.4–1.5)

AD, Alzheimer’s disease; CVD, cerebrovascular disease; VaD, vascular dementia.