Table 2.

Preclinical miRNA studies in medulloblastoma

miRNA	Mechanism	Cell Line	Administration	Carrier Format	Tumor Site	Effect	Reference
miR-124	overexpression	D425	In vitro	Lentivirus	Flank/intracranial	Growth inhibition	73
miR-192	miRNA mimics	D283	In vivo, intranasal	Nanoparticle	Intracranial	Metastases Inhibition	85
miR-34a	Overexpression	Daoy	In vitro	Adenovirus	Flank/intracranial	Growth inhibition	54
miR-199b-5p	Overexpression	Daoy	In vitro	Adenovirus	Flank/intracranial	Growth inhibition	52
miR-31	Overexpression	Daoy	In vitro	Transfection	Flank	Growth inhibition	74
miR17‒92	Anti-miRNA	Ptch1+/−, Trp53 −/− medulloblastoma cells	In vivo, intra venously	LNA	Flank/intracranial	Growth inhibition	40