Table 4.
Hematological and nonhematological toxicity grades 1/2 and 3/4*
| Toxicity Type | Radiochemotherapy (% of affected patients) | Radiochemotherapy (no. of events) | Adjuvant Chemotherapy (% of affected patients) | Adjuvant Chemotherapy (no. of events) | Active Treatment Phase
(% of affected patients) |
Active Treatment Phase (no. of events) |
|---|---|---|---|---|---|---|
| Grades 1/2 | ||||||
| Leukopenia | 53.3 | 16 | 66.7 | 62 | 76.7 | 78 |
| Thrombocytopenia | 56.7 | 17 | 50.0 | 46 | 76.7 | 63 |
| Anemia | 70.0 | 21 | 40.0 | 111 | 86.7 | 132 |
| Infection | 23.3 | 7 | 16.7 | 12 | 30.0 | 19 |
| Nausea | 66.7 | 20 | 46.7 | 39 | 73.3 | 59 |
| Emesis | 30.0 | 9 | 16.7 | 13 | 36.7 | 22 |
| Polyneuropathy | 30.0 | 9 | 63.3 | 81 | 70.0 | 81 |
| Ototoxicity | 10.0 | 3 | 23.3 | 33 | 23.3 | 36 |
| Grades 3/4 | ||||||
| Leukopenia | 36.7 | 11 | 66.7 | 68 | 56.7 | 79 |
| Thrombocytopenia | 3.3 | 1 | 36.7 | 33 | 40.0 | 34 |
| Anemia | 13.3 | 4 | 20.0 | 20 | 20.0 | 24 |
| Infection | 10.0 | 3 | 0.0 | 0 | 20.0 | 3 |
| Nausea | 6.7 | 2 | 0.0 | 0 | 13.3 | 2 |
| Emesis | 3.3 | 1 | 0.0 | 0 | 6.7 | 1 |
| Polyneuropathy | 16.7 | 5 | 20.0 | 12 | 26.7 | 12 |
| Ototoxicity | 0.0 | 0 | 20.0 | 1 | 3.3 | 1 |
*According to Common Terminology Criteria for Adverse Events v3.0.
Note. Toxicity was evaluated during radiochemotherapy and during maintenance chemotherapy. Percents were calculated in relation to patients under treatment at the respective time points.