Fig. 5.

Molecular differences between uMGMT and mMGMT progressive glioblastomas. (A) CNV of CDK4, MDM2, PDGFRA, and CDKN2A in the cohort of the progressive tumors, grouped according to MGMT promoter methylation. (B) Comparison of CDK4, MDM2, and PDGFRA copy number variations between mMGMT and uMGMT tumors in the progressive situation. (C) Heatmap of CNVs of a set of 19 frequently altered genes in the progressive tumor collective. High frequencies of alterations are shown in red, low frequencies in blue. MGMT promoter methylation is indicated in the first row. (D) Copy number variation profiles in mMGMT and uMGMT tumors in the progressive situation.