Figure 2.

Effects of prenatal FM 550 exposure on the relative abundance of genes related to inflammatory signaling in placental tissue. Significant upregulation of Cxcl10 and Ccl5 was observed at the highest dose when males and females were group for analysis (A and C). Similarly, significant upregulation was observed at the highest dose for Cxcl10 and Ccl5 in males and females when analyzed by sex (B and D). No significant effect of exposure was observed for Ccr7 when combined for analysis (E), however, when analyzed by sex, high-dose females showed a significant increase in expression (F). For each dose n = 7/sex. Graphs depict median with whiskers from minimum to maximum (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001).