Figure 6.

Effects of prenatal FM 550 exposure on neurotransmitter and neurotransmitter metabolite levels in fetal forebrain. 5-HT levels were not significantly altered in fetal forebrain (A) although there was a trend for higher levels in females (B). No significant effect of exposure was observed for 5-HIAA (C); however, a significant difference between male and female controls was observed (D). A significant reduction in the ratio of 5-HIAA:5-HT was observed at the highest dose but only in females (F). No significant effect of exposure was found for tryptophan or DOPAC:DA (G, H, I and J). For each dose group n = 6/sex. Graphs depict median with whiskers from minimum to maximum (*P ≤ 0.05).