. Author manuscript; available in PMC: 2018 Sep 18.

Published in final edited form as: J Reprod Immunol. 2017 Sep 18;123:72–77. doi: 10.1016/j.jri.2017.09.006

Table 1.

Summary of major advances in immunology of reproduction these last 2 decades.

Major advances in Immunology of Reproduction	Redman and Sargent, 2010
Lack of HLA-G in PE (1990’s) Role of cytokines (Th1/Th2 paradigm) (1990’s) Immunological role of seminal fluid (TGF β) Tremelen & Sarah Robertson (1998) Pivotal role of NK cells (implantation and angiogenesis) BA. Croy, A. Moffett, S. Hiby (2000–2004) Dysregulation of angiogenic factors by complement activation Girardi et al JEM 2006 203(9):2165–75 Role of hyperglycosylated HCG (deepness of implantation) (≈ 2007), Laurence Cole Immunological animal model for PE (Girardi, 2008) Pivotal role of T Reg cells (≈ 2010’s)

Major advances in Immunology of Reproduction

Lack of HLA-G in PE (1990’s)
Role of cytokines (Th1/Th2 paradigm) (1990’s)
Immunological role of seminal fluid (TGF β)

Tremelen & Sarah Robertson (1998)
Pivotal role of NK cells (implantation and angiogenesis)

BA. Croy, A. Moffett, S. Hiby (2000–2004)
Dysregulation of angiogenic factors by complement activation Girardi et al JEM 2006 203(9):2165–75
Role of hyperglycosylated HCG (deepness of implantation) (≈ 2007), Laurence Cole
Immunological animal model for PE (Girardi, 2008)
Pivotal role of T Reg cells (≈ 2010’s)