. Author manuscript; available in PMC: 2018 Feb 19.

Published in final edited form as: Am J Orthop (Belle Mead NJ). 2016 Nov-Dec;45(7):E439–E443.

Table 2.

Primary Outcomes for Primary Total Hip and Knee Arthroplasty

THA	IV TXA (n = 108)	Topical TXA (n = 48)	P
Mean (SD)
Preoperative Hgb, g/dL	13.8 (1.31)	13.7 (1.40)	.625
Postoperative Hgb, g/dL	10.5 (1.63)	10.8 (1.65)	.134
Hgb decrease, g/dL^a	3.33 (1.02)	2.89 (1.44)	.031
Estimated blood loss, mL	509.3 (25.8)	557.3 (38.6)	.303
Calculated blood loss, mL	1287.3 (41.5)	1226 (62.2)	.418

Transfusions, n (%)	8 (7%)	5 (10%)	.538

Cost, $^a	1161	2100	≤.0001

TKA	IV TXA (n = 83)	Topical TXA (n = 52)	P

Mean (SD)
Preoperative Hgb, g/dL	13.8 (1.27)	13.8 (1.23)	.861
Postoperative Hgb, g/dL	11.5 (1.43)	11.8 (1.13)	.107
Hgb decrease, g/dL^a	2.35 (0.988)	1.93 (0.900)	.015
Estimated blood loss, mL	101.1 (89.4)	102.6 (105.1)	.93
Calculated blood loss, mL^a	1084.2 (605.4)	859.6 (386.6)	.019

Transfusions, n (%)	2 (2%)	1 (2%)	.26

Cost, $^a	1271	2100	≤.0001

Abbreviations: Hgb, hemoglobin; IV, intravenous; THA, total hip arthroplasty; TKA, total knee arthroplasty; TXA, tranexamic acid.

Significant difference.