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. 2018 Feb 6;90(6):e518–e524. doi: 10.1212/WNL.0000000000004932

Figure 1. Plasma neurofilament light (NfL) concentration in Charcot-Marie-Tooth disease (CMT).

Figure 1

(A) Significantly increased plasma NfL concentration in patients with CMT (n = 75) compared to healthy controls (n = 67). (B) Significantly increased plasma NfL concentration in patients with more severe disease (weighted CMT examination score [CMTES] >10) vs milder CMT (weighted CMTES <10) and healthy controls. (C) Plasma NfL concentration for the 3 largest subgroups of CMT, CMT1A (n = 31), hereditary sensory neuropathy due to mutations in SPTLC1 (n = 20), and CMTX1 (n = 11).