Fig. 1.

Incorporation of β-actin and γ-actin into distinct actin networks. Although they can overlap, β-actin and γ-actin isoforms have been shown to exhibit different cellular localizations. Illustrated here is a scenario where β-actin is enriched in the lamellipodia and γ-actin in actin arcs and/or stress fiber structures. β-actin-encoding mRNA is also localized and locally translated at the leading edge. Arginylation of β-actin (Arg) promotes localization and assembly in lamellipodia but targets γ-actin for degradation, as depicted by the pale color.