Table 1.

D:A:D cardiovascular disease 5-year risk score

Factor	Unit
Age	Years
Sex	Male/female
Previous smoker	Yes/no
Current smoker	Yes/no
Family CVD history	Yes/no
Diabetes	Yes/no
Abacavir treatment	Yes/no
Protease inhibitor exposure	Years
NRTI exposure	Years
Time-updated CD4 cell count	Cells/µL
Systolic blood pressure	mm Hg
Total cholesterol	mmol/L
HDL	mmol/L

Estimation of the predicted 5-year risk is done using Cox models.

The full D:A:D model includes all the covariates listed above and is used when cumulative NRTI exposure is up to 10 years and PI exposure is up to 6 years. For individuals who are highly exposed to either NRTIs or PIs, a simpler D:A:D model is used to prevent overestimation of CVD risk. The simpler model excludes the covariates for abacavir treatment, PI and NRTI exposure times.

A more detailed explanation of the D:A:D equation is given in the online supplementary appendix 1.

CVD, cardiovascular disease; D:A:D, Data Collection on Adverse Events of Anti-HIV Drugs; HDL, high-density lipoprotein; NRTI, nucleoside reverse-transcriptase inhibitor; PI, protease inhibitor.