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. 2018 Jan 1;11(1):dmm029082. doi: 10.1242/dmm.029082

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Jp levels modify the phenotype of pathological Htt and SCA3 poly-Q expansions. (A-A″) Progressive degeneration and depigmentation over 4 weeks upon expression of Htt-pQ93 in the eye driven by GMR-Gal4. (B-B″) Coexpression of Jp ameliorates the depigmentation. (C-C″) Coexpression of jp RNAi induces earlier, faster progressing depigmentation. GMR-Gal4 alone (D), GMR-Gal4-driven UAS-jp (E) or UAS-jp^RNAi (F) does not produce any depigmentation at 4 weeks. (G) Expression of SCA-Q89 produces eye depigmentation that is evident at 4 weeks. (H) Coexpression of Jp reduces depigmentation. (I) Coexpression of jp RNAi increases depigmentation.