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. 2018 Jan 1;11(1):dmm029082. doi: 10.1242/dmm.029082

Fig. 5.

Fig. 5.

Jp levels modify the phenotype of pathological Htt and SCA3 poly-Q expansions. (A-A″) Progressive degeneration and depigmentation over 4 weeks upon expression of Htt-pQ93 in the eye driven by GMR-Gal4. (B-B″) Coexpression of Jp ameliorates the depigmentation. (C-C″) Coexpression of jp RNAi induces earlier, faster progressing depigmentation. GMR-Gal4 alone (D), GMR-Gal4-driven UAS-jp (E) or UAS-jpRNAi (F) does not produce any depigmentation at 4 weeks. (G) Expression of SCA-Q89 produces eye depigmentation that is evident at 4 weeks. (H) Coexpression of Jp reduces depigmentation. (I) Coexpression of jp RNAi increases depigmentation.