Table 2.
Correlation Between Expression of HOTAIR and Clinicopathological Characteristics of Cancers.
| Clinical Parameters | No. of Studies | No. of Patients | OR (95% CI) | P-Value | Heterogeneity | |
|---|---|---|---|---|---|---|
| I2 (%) | P Value | |||||
| Age (elderly vs young) | 11 | 1045 | 0.81 (0.62-1.05) | .113 | 0 | .915 |
| Gender (male vs female) | 14 | 1277 | 1.12 (0.88-1.43) | .346 | 0 | .857 |
| Tumor size (large vs small) | 9 | 924 | 1.08 (0.80-1.46) | .617 | 44.8 | .080 |
| Differentiation (poor vs well) | 5 | 386 | 1.65 (1.02-2.65) | .040 | 78.5 | .001 |
| TNM stage (III + IV vs I + II) | 6 | 460 | 3.58 (2.43-5.30) | <.001 | 29.2 | .205 |
| Lymph node metastasis (present vs absent) | 11 | 967 | 2.52 (1.89-3.36) | <.001 | 0.0 | .457 |
| Distant metastasis (present vs absent) | 4 | 403 | 4.20 (2.17-8.14) | <.001 | 39.1 | .177 |
Abbreviation: HOTAIR, HOX transcript antisense intergenic RNA.