Table 4.
Change in fatigue (mFIS score) in subgroups (modified FAS).
| Fatigue (mFIS score) |
||||
|---|---|---|---|---|
| SubgroupIntervention group | N | BaselineMean ± SDa | Differencemonth 6—baselineMean (95% CI)b | p valueb |
| Low aerobic capacity (VO2max < 27 l/min/kg) | ||||
| E-training | 16 | 36.0 ± 15.4 | –10.60 (–17.60; –3.54) | |
| Waiting | 26 | 37.3 ± 12.5 | –1.40 (–7.53; 4.72) | |
| Difference e-training—waiting | –9.19 (–17.20; –1.22) | 0.025 | ||
| Moderate aerobic capacity(VO2max 27 to 31 l/min/kg) | ||||
| E-training | 17 | 28.1 ± 13.6 | 0.58 (–5.84; 7.00) | |
| Waiting | 33 | 34.0 ± 13.6 | –1.61 (–5.72; 2.50) | |
| Difference e-training—waiting | 2.19 (–4.88; 9.26) | 0.536 | ||
| High aerobic capacity (VO2max > 31 l/min/kg) | ||||
| E-training | 23 | 28.4 ± 14.2 | –1.84 (–6.28; 2.60) | |
| Waiting | 24 | 32.8 ± 15.2 | –4.33 (–8.61; –0.05) | |
| Difference e-training—waiting | 2.49 (–3.70; 8.68) | 0.422 | ||
| Low aerobic capacity (VO2max ≤ 30 l/min/kg)*high fatigue (mFIS > 32) | ||||
| E-training | 13 | 46.0 ± 9.1 | –12.80 (–21.00; –4.56) | |
| Waiting | 30 | 44.9 ± 8.2 | –2.65 (–8.48; 3.18) | |
| Difference e-training—waiting | –10.10 (–19.00; –1.27) | 0.026 | ||
| High aerobic capacity (VO2max > 30 l/min/kg)*low fatigue (mFIS ≤ 32) | ||||
| E-training | 16 | 20.0 ± 5.9 | 0.17 (–4.84; 5.19) | |
| Waiting | 16 | 22.1 ± 8.1 | –0.52 (–5.42; 4.38) | |
| Difference e-training—waiting | 0.69 (–6.54; 7.93) | 0.846 | ||
aUnadjusted raw means.
bResult from analysis of covariance model for difference in mFIS between baseline and month 6 with predictors baseline EDSS, mFIS (only for subgroups defined by aerobic capacity alone), sex and intervention group.
CI: confidence interval; EDSS: Expanded Disability Status Scale; FAS: full analysis set; mFIS: Modified Fatigue Impact Scale; N: number of patients; SD: standard deviation; WEIMuS: Würzburg Fatigue Inventory for MS scale.
The mFIS score ranges from 0 (not tired) to 84 (tired).