Figure 1.
Amino acid sequence differences within residues 1–250 of HIV-1BH10 and HIV-2ROD RTs and mutant HIV-2ROD RTs analyzed in this study. a, sequence alignments showing differences between HIV-1 and HIV-2 RTs at positions associated with the excision pathway of resistance to thymidine analogues. Differences between both RTs are highlighted in red. Amino acids shown in blue were introduced in one or more HIV-2ROD mutant RTs generated in this study. b, HIV-2ROD RTs analyzed in this study and their abbreviated designations.