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. 2017 Dec 27;293(7):2597–2605. doi: 10.1074/jbc.M117.813667

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Figure 3. — Effect of seeding on Httex1(Q46) aggregation. a, ThT fluorescence kinetics for the 15 μm 35R1 Httex1(Q46) derivative in the presence (red) and absence (black) of 10% (1.5 μm) seeds. b, acceleration of Httex1(Q46) aggregation in the presence of seeds (red) monitored via EPR kinetics for 35R1 derivative. The control without seed is shown in black. c, EPR-based kinetics for spin-labeled Httex1(Q46) derivatives (9R1, blue curve; 35R1, red curve) show very similar kinetics, indicative of similar rates of aggregation in the respective regions.