Table 3.

Association of cluster with outcomes in SPS3 participants (among participants in the lower BP target group).

		LOWER SBP TARGET GROUP			HIGHER SBP TARGET GROUP

Outcome	Cluster	Event Rate per 1000 PY	Demographic-adjusted^a HR (95% CI)	Multivariable-adjusted^b HR (95% CI)	Event Rate per 1000 PY	Multivariable-adjusted^b HR (95% CI)
Mortality	1	11.2 (7.8, 16.0)	ref	ref	13.3 (9.5, 18.8)	ref
	2	20.0 (14.7, 27.1)	1.71 (1.07, 2.75), p=0.026	1.64 (1.01, 2.67), p=0.046	12.3 (8.2, 18.6)	0.92 (0.54, 1.59), p=0.77
	3	27.3 (17.2, 43.3)	2.30 (1.25, 4.21), p=0.0071	2.30 (1.20, 4.42), p=0.012	33.3 (20.7, 53.6)	2.84 (1.53, 5.26), p=0.0009

MVE^*	1	18.0 (13.3, 24.3)	ref	ref	35.2 (28, 44.2)	ref
	2	41.1 (32.6, 51.9)	2.28 (1.55, 3.34), p<.0001	2.13 (1.44, 3.15), p=0.0002	33.4 (25.5, 43.7)	0.95 (0.66, 1.37), p=0.78
	3	28.0 (17.1, 45.7)	1.51 (0.82, 2.77), p=0.18	1.67 (0.89, 3.11), p=0.11	39 (24.2, 62.7)	1.14 (0.65, 2.01), p=0.65

Stroke^**	1	12.3 (8.5, 17.7)	ref	ref	27.7 (21.5, 35.8)	ref
	2	34.3 (26.6, 44.2)	2.76 (1.77, 4.31), p<.0001	2.63 (1.67, 4.13), p<.0001	27.4 (20.4, 36.8)	1.01 (0.67, 1.51), p=0.97
	3	18.9 (10.5, 34.2)	1.45 (0.69, 3.05), p=0.32	1.62 (0.76, 3.46), p=0.21	34.2 (20.6, 56.7)	1.28 (0.69, 2.38), p=0.43

Model 1 = age, sex, race, and education level.

Model 2 adjusts for model 1 plus cardiovascular risk factors (smoking, baseline cholesterol, baseline diabetes, baseline cardiovascular disease (congestive heart failure or coronary heart disease), body mass index).

^a,b

For MVE and stroke, Fine-Gray competing-risk analysis accounts for competing risk of death

MVE = stroke, myocardial infarction, or vascular death

^**

Stroke = Ischemic or hemorrhagic stroke (primary study outcome)