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. 2017 Jul 4;9(2):178–195. doi: 10.1007/s13238-017-0437-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Amino acid sequence alignments of human and murine carboxylesterases reported to hydrolyze lipids. Boxed residues indicate conserved functional residues and domains: 1, oxyanion hole-forming domain; 2, GXSXG catalytic serine motif; 3, catalytic glutamic acid; 4, catalytic histidine; NLBD, putative neutral lipid binding domain. The HXEL ER retrieval sequence is indicated with bold letters. Residues that comprise the rigid pocket on CES1 are indicated with arrows. GenBank accession numbers: CES1, NP_001257; CES2, NP_003860; CES3, NP_079198; Ces1d, NP_444430; Ces1e, NP_598421; Ces1g, NP_067431; Ces2c, NP_663578; Ces2g, NP_932116