Table 1.
Neurodegenerative diseases with abundant tau inclusions.
| 3R + 4R Tauopathies |
| Alzheimer’s disease |
| Amyotrophic lateral sclerosis/parkinsonism-dementia complex |
| Anti-IgLON5-related Tauopathy |
| Chronic traumatic encephalopathy |
| Diffuse neurofibrillary tangles with calcification |
| Down’s syndrome |
| Familial British dementia |
| Familial Danish dementia |
| Gerstmann–Sträussler–Scheinker disease |
| Niemann–Pick disease, type C |
| Non-Guamanian motor neuron disease with neurofibrillary tangles |
| Postencephalitic parkinsonism |
| Progressive ataxia and palatal tremor |
| Tangle-only dementia |
| Familial frontotemporal dementia and parkinsonism (some MAPT mutations, such as V337M and R406W) |
| 3R Tauopathies |
| Pick’s disease |
| Familial frontotemporal dementia and parkinsonism (some MAPT mutations, such as G272V and Q336R) |
| 4R Tauopathies |
| Argyrophilic grain disease |
| Corticobasal degeneration |
| Guadeloupean parkinsonism |
| Globular glial Tauopathy |
| Huntington’s disease |
| Progressive supranuclear palsy |
| SLC9A6-related parkinsonism |
| Tau astrogliopathy |
| Familial frontotemporal dementia and parkinsonism (some MAPT mutations, such as P301L and P301S, all known intronic mutations, and many coding region mutations in exon 10) |