Figure 2.

CD4⁺ and CD8⁺ T cells protect mice after DEC‐gag protein‐prime rNDV‐L‐gag‐boost vaccine. Mice vaccinated as indicated in x‐axis of Figure 3(a–d) above were treated as indicated with control rat IgG or depleting antibodies to αCD4, αCD8, or both (αCD4 & αCD8) at days −3, −2, −1 prior to airway challenge with recombinant vaccinia‐gag virus. Lung virus titer (PFU/lung) was determined 7 days after challenge with recombinant vaccinia‐gag virus (Mean ± SD of three repeat experiments) (ns, not significant (two tailed student's t test).