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. 2017 Dec 4;6(1):163–175. doi: 10.1002/iid3.209

Figure 3.

Figure 3

Complementary DEC‐gag protein prime rNDV‐L‐gag boost vaccine allows for enhanced accumulation of CD8+ T cells to an infection challenge site. CxB6F1 mice vaccinated as described in Figures 3, 4 were assessed for tetramer binding CD8+ T cells in the spleen and the lungs as the infection site. HIV gag specific CD8+ T cells were enumerated by binding of tetramers formed from H‐2Kd and HIV gag peptide (AMQMLKETI). (a) FACS data to illustrate gating schema for tetramer binding CD8+ T cells in lungs and spleen 10d after rNDV‐Lgag boost vaccine. (b) As in (a) Female CXB6 F1 mice were vaccinated as indicated in the y‐axis and 10 days lungs are dissociated to determine tetramer binding cells. (c) as in (a) but mean ± SD of three experiments. (d) as in (b) but 50 days after the rNDV‐L‐gag boost (*p = 0.05 student's t test). (e) as in (c) mean ± SD of three experiments 50 days after rNDV‐L‐gag boost.