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. 2017 Nov 9;6(1):128–142. doi: 10.1002/iid3.205

Figure 1.

Figure 1

AIRmin mice are more susceptible to pneumococcal infection than AIRmax mice. Animals were submitted to intranasal pneumococcal challenge with the serotype 3 ATCC6303 (A, E, and F), the serotype 1 ATCC6301 (B) or the serotype 11A M10 strains (C and D). In A and B, survival of mice was monitored for 10 days. **p < 0.01, Log‐Rank survival curve (Comparison between AIRmin and AIRmax). Curves were composed with the results of two independent experiments. Numbers indicate alive/total animals in each group. In C and D mice (6 per group) were euthanized 24 h post‐infection; in E and F mice (4 to 6 per group) were euthanized at different time‐points post‐infection and bacteria were recovered from BALF or lungs. Circles represent each individual and lines represent the medians of the groups. *p < 0.05, **p < 0.01, ***p < 0.001, Unpaired T test (C and D) and Two‐way ANOVA, with Tukey's post‐test (E and F). Results from C, D, E and F represent at least two independent experiments.