Figure 4.

Cytokines and chemokines were induced in response to pneumococcal challenge in both AIRmin and AIRmax mice. Animals (4 to 6 per group) were submitted to intranasal pneumococcal challenge with ATCC6303 strain. Mice were euthanized at different time‐points post‐challenge and BALF were collected for the analysis of cytokines and chemokines by Luminex. Results were expressed by means for each group with SD and are representative of two independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001 Two‐way ANOVA with Tukey's post‐test.