Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 19;8:3263. doi: 10.1038/s41598-018-21586-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Aplysia Ca_V2α1, Ca_Vβ, and Ca_V α2δ alternate sequence locations from the available transcriptome data. (A) Cartoon layout of the Aplysia Ca_V2α1 subunit showing the four (I–IV) domain repeats, each with 6 transmembrane spanning regions. The relative locations of four alternate sequence inserts indicative of alternate cassette exons are highlighted in light grey ovals and numerically labeled; two in the domain I-II linker loop (1&2), one in the C-terminus (5), and one in an extracellular IIIS3-S4 linker (3). The location of an alternate sequence in a constitutive region of domain IV is highlighted in dark, thick line (4). The location of the EF-hand with Y1501 is labeled with a Y. The cytosolic Ca_Vβ subunit has at least two potential isoforms generated with an alternate start site producing subunits with distinct N-termini (6). The extracellular α2 subunit also has a variety of isoforms with two regions coding alternate sequences; the first with three potential sequences (7) and the second site is an alternate cassette exon (8). (B) Table of alternate sequence locations, isoform variations, and specific isoform sequences for the three cloned Aplysia Ca_V subunits.