Figure 3.

PfEMP1 domain and DC annotation of var genes reconstructed using the Pf3k database. Domain boundaries were defined by the VarDom 1.0 Server and individual domains BLAST searched against the 7 genomes dataset in Rask et al.⁴. The top hits were analysed and domain subtypes identified based on consensus sequence and coverage. Where multiple subtypes were identified, both are shown if they are of equal standing (e.g. 0.4/12) or excluded if more than two subtypes displayed similar coverage. Dashed lines outline domain cassettes (DC) with the DC number shown in the far-right column. ND: not defined, no matches by BLAST search.