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. 2018 Feb 19;8:3305. doi: 10.1038/s41598-018-21642-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of apoptosis by SSE15206. (A) SSE15206 induces cleaved PARP and p53. HCT116, A549, and CAL-51 cells were treated with 0.5 μM, 1 μM and 2 μM SSE15206 for 24 hours and levels of cleaved PARP, p53, and p21 were analyzed by western blotting using specific antibodies. Alpha-tubulin was used as loading control. (B) Increased Annexin V/PI staining in cells treated with SSE15206. Cells treated with 1 μM and 2 μM SSE15206 for 24 and 48 hours were stained with FITC-labelled Annexin V/PI and analyzed by FACS. The left panel shows FACS data for cells treated for 48 hours, whereas the graph on the right shows quantification of cells treated with two concentrations of SSE15206 for 24 and 48 hours (One-way ANOVA 24 h: F (2,6) = 5.309, p < 0.05; post-hoc: SSE15206 1 μM vs. DMSO *p < 0.05, SSE15206 2 μM vs. DMSO *p < 0.05; One-way ANOVA 48 h: F (2, 6) = 13.05, p < 0.01; post-hoc SSE15206 1 μM vs. DMSO **p < 0.01, SSE15206 2 μM vs. DMSO **p < 0.01).