Table 1.

A. GI₅₀ values of compounds in relation to their structure, in a three-day SRB proliferation assay in HCT116 cells. Values are presented as an average of at least three independent experiment together with standard deviation

Compound	R1	R2	R3	R4	R5	GI50 values (µM) ± SD	n
A
SSE15201	H	H	H	H	H	5.76 ± 0.18	4
SSE15202	H	H	NO2	H	H	3.26 ± 0.11	4
SSE15203	H	H	H	MeO	H	5.02 ± 0.12	4
SSE15204	H	H	H	F	H	>50	4
SSE15205	MeO	H	H	H	H	8.69 ± 0.37	4
SSE15206	H	H	MeO	MeO	MeO	0.197 ± 0.05	3
SSE15207	H	H	H	BnO	H	1.30 ± 0.13	4
SSE15208	BnO	H	H	H	H	7.76 ± 0.19	4
SSE15209	BnO	H	H	Cl	H	20.55 ± 2.04	4
SSE15210	BnO	H	MeO	H	H	13.87 ± 0.19	4
SSE15211	BnO	H	H	MeO	H	8.71 ± 0.31	4
SSE15212	BnO	H	H	F	H	>50	4
SSE15213	BnO	Cl	H	H	H	12.19 ± 0.14	4
SSE15214	MeC6H4CH2O	H	H	H	H	6.98 ± 0.13	4
SSE15215	MeC6H4CH2O	H	H	F	H	9.88 ± 0.11	4
SSE15216	MeC6H4CH2O	H	H	Cl	H	13.94 ± 0.05	4
B
Cancer Type		Cell line				GI 50 values (µM) ± SD
Breast		BT-549				0.445 ± 0.298 (n = 2)
		CAL-51				0.286 ± 0.15 (n = 2)
		MDA-MB-231				0.756 ± 0.077 (n = 3)
Leukemia		MOLM-13				0.264 ± 0.046 (n = 2)
		MV-4-11				0.362 ± 0.037 (n = 2)
		K562				0.776 ± 0.467 (n = 2)
Colorectal		HCT116				0.197 ± 0.049 (n = 3)
		DLD-1				0.505 ± 0.239 (n = 4)
		HCT-15				0.145 ± 0.046 (n = 3)
Lung		A549				1.2692 ± 0.401 (n = 2)
Cervical		HeLa				0.173 ± 0.031 (n = 3)
Ovarian		A2780				0.145 ± 0.006 (n = 2)

B. GI₅₀ values of the most potent compound, SSE15206 in cancer cell lines of different origins in a three-day SRB proliferation assay.