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. 2018 Feb 19;8:3252. doi: 10.1038/s41598-018-21663-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis of expression data. (A) The top enriched function in each category is plotted with the log p-value. The significance threshold is marked. (B) Mesenchymal network derived from the upstream/master regulators found in the expression dataset. (C) Gene Set Enrichment Analysis (GSEA) of the mesenchymal hallmark signature. Left Panel: The enrichment score is compared with the up-regulated (left) and down-regulated (right) genes. The False Discovery Rate is also shown. Right Panel: The top regulated genes found in the analysis. Lighter gray, higher expression. Darker gray, lower expression. (D) The Hedgehog pathway is enriched in the ovarian fibrosarcoma sample. Gray tones represent expressional changes.