Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 19;8:3269. doi: 10.1038/s41598-018-21641-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

RT-QuIC profiles of human brain extracts from the molecular subgroups of AD. Soluble fractions from AD brain homogenates were diluted in 100 mM Tris-HCl pH 7.5, 5 μM ThT, 4 μM Aβ1-42_WT (panel a) or Aβ1-42_A2V (panel and b). ThT intensity was normalized to the corresponding maximal ThT fluorescence and expressed as relative arbitrary units (a. u. %). Comparison of aggregation kinetics of brain extracts from AP1 and AP2 profiles and APP_A673V, APP_A713T and sAD1 subjects (a). Each brain sample was analyzed in quadruplicate. Data are shown as mean ± SEM. Comparison of aggregation kinetics of APP_A673V brain extract when co-incubated with Aβ1-42 wild-type or Aβ1-42 carrying the A2V mutation, corresponding to A673V substitution on APP gene (b). Each brain sample was analyzed in triplicate. Data are shown as mean ± SEM.