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. 2018 Feb 19;8:3269. doi: 10.1038/s41598-018-21641-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Amyloid burden in mice injected with human brain extracts from distinct molecular profiles of Alzheimer’s disease. Mice inoculated with an Alzheimer brain homogenate from AP1 subgroup (a–d), AP2 subgroup (e–h), APP_A713T (fAD2) (i–l), APP_A673V (fAD1) (m–p), sAD1 case (q–t) and control groups, i.e. age-matched noninjected mice (u–x) and mice injected with Aβ-immunodepleted brain extracts (aa–dd). (a,e,i,m,q,u,aa) Amyloid deposits, scale bar 0,5 mm. (b,f,j,n,r,v,bb) Congophilic amyloid angiopathy, 300 µm. (c,g,k,o,s,w,cc) Intraneuronal Aβ immunoreactivity, scale bar 120 µm. (d,h,l,p,t,x,dd) Amyloid plaques, scale bar 120 um. Immunostaining with 4G8 antibody.