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Gephyrin E-domain binding enthalpy and binding entropy of GlyR β-loop wild-type determined by ITC
| Parameter | β-Loop variant | One-site model4 |
|---|---|---|
| ΔH [kcal/mol]1 | βL-wt3 | –16.1 ± 0.5 |
| ΔS [cal/mol * K]2 | βL-wt3 | –26.8 ± 2.1 |
Mean values and SEM from five independent measurements.
1Binding enthalpy (ΔH in kcal/mol).
2Binding entropy (ΔS in cal/mol * K).
3GlyR β-loop residues 378–426.
4Binding isotherm fitted to a one-site interaction with gephyrin E-domain.
