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. 2018 Feb 19;8:3295. doi: 10.1038/s41598-018-21212-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exogenous and endogenous matrix degradation work synergistically to enhance cell migration. (a) SHG signal (green) of substrates showing altered fibrillar collagen structure with collagenase digestion. Arrows indicate inter-fibrillar regions. Scale = 20 µm. (b) Area fraction and average diameter of inter-fibrillar regions (n = 10 samples/group, mean ± SEM). (c) Top-down and cross-sectional 3D confocal reconstruction of adult meniscal cells (green) on tissue substrates (blue). Arrows point to infiltrating cells. Scale = 20 µm (top) and 10 µm (bottom). (d) Average and (e) cumulative frequency distribution of cell infiltration depth (n = 100 cells/group, mean ± SEM). *p < 0.05 vs. all other groups.