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. 2018 Feb 19;8:3295. doi: 10.1038/s41598-018-21212-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modulating matrix microstructure in the absence of altered micromechanics improves cell migration. (a) SHG signal (green) of substrates showing fibrillar collagen structure with chondroitinase ABC (ChABC) digestion. Scale = 25 µm. Inset shows Alcian Blue staining of tissue proteoglycans. Scale = 100 µm. (b) Area fraction and average diameter of inter-fibrillar regions (n = 5 samples/group, mean ± SD). (c) Local indentation modulus of Adult tissues after digestion with varying concentrations of ChABC, normalized to untreated Control (n = 55–58 indentations/group, mean ± SEM). (d) Top down confocal images of adult meniscal cells (green) on tissue substrates (blue). Scale = 50 µm. (e) Average and (f) cumulative frequency distribution of infiltration depth (n = 70–80 cells/group, mean ± SEM). ^#p < 0.05 vs. Control. *p < 0.05 vs. all other groups.