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. 2017 Nov 3;102(3):373–379. doi: 10.1007/s00223-017-0359-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Domain structure of COL1A1 protein with p.Gly22Arg substitution in the signal peptide highlighted in blue. b Prediction of the cleavage site probability of the wt COL1A1 sequence and the p.Gly22Arg substitution using the SignalP algorithm. The algorithm predicts a strong reduction of the cleavage site probability (from 0.956 to 0.319) for the p.Gly22Arg substitution. The predicted cleavage site for the Gly22Arg substitution with the highest probability is at a different position (between Gly30 and Gln31). A black arrow indicates the position of the wt signal peptide cleavage site; n-region: N-terminal region; h-region: hydrophobic region; c-region: cleavage region (Color figure online)