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. 2017 Oct 23;92(2):705–716. doi: 10.1007/s00204-017-2077-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Schematic model of how PFOS may promote cell-cycle progression, and stimulate cell proliferation and transformation in MCF-10A cells. PFOS acts through ER and possibly VEGR/HER2, up-regulating CDK4 and down-regulating p27, p21, and p53, to drive cells into the cell cycle from G₁ to S, promoting cell-cycle progression