. 2017 Oct 16;92(2):833–844. doi: 10.1007/s00204-017-2089-4

Table 1.

Pharmacological signature of expressed GABA_A receptor isoforms

GABA_A isoform	Sensitivity to positive allosteric modulators	Sensitivity to inhibitors
α1β12γL	Diazepam⁺, Propofol⁺, Allopregnanolone⁺	SAS⁺, Bicuculline⁺, Fipronil⁺
α1β2γ2L	Diazepam⁺, Propofol⁺, Allopregnanolone⁺	Fipronil⁺
α1β3γ2L	Diazepam⁺, Propofol⁺, Allopregnanolone⁺	Fipronil⁺
α2β2γ2L	Diazepam⁺, Propofol⁺	Fipronil⁺
α2β3γ2L	Diazepam⁺, Propofol⁺, Allopregnanolone⁺	SAS^neg, Bicuculline⁺, Fipronil⁺, Zn^2+neg
α2β3	Diazepam^neg, Propofol⁺,	Fipronil⁺
α4β3γ2L	Diazepam^neg, Propofol⁺,	Fipronil⁺
α4β3δ	Diazepam^neg, Allopregnanolone⁺, DS2⁺	Fipronil⁺
α6β1γ2L	Diazepam^neg	SAS⁺, Bicuculline⁺, Fipronil⁺
α6β2γ2L	Diazepam^neg, Propofol⁺	Fipronil⁺
α6β3γ2L	Diazepam^neg, Propofol⁺, Allopregnanolone⁺	SAS^neg, Bicuculline⁺, Fipronil⁺, Zn^2+neg
α6β3	ND	Zn²⁺ positive
α6β3γ1	Diazepam^neg, Propofol⁺	Fipronil⁺
α6β3δ	Diazepam^neg, DS2⁺	Fipronil⁺

Sensitivity to 10 μM diazepam, 250 nM Allopregnanolone, 100 μM Propofol, 50 μM DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide), 10 μM Fipronil, 100 μM Bicuculline, 10 μM SAS (salicylidene salicylhydrazide) and 10 μM ZnCl₂ was tested on 3–10 cells per subunit combination

ND Not determined