Table 2.
IC50 values for TETS and PTX
| GABAA isoform | TETS (μM) | 95% CI | PTX (μM) | 95% CI |
|---|---|---|---|---|
| α1β1γ2L | > 20 | – | > 30 | – |
| α1β2γ2L | 3.60 | 2.1–4.1 | 7.98 | 6.58–9.38 |
| α1β3γ2L | 3.41 | 1.4–5.4 | 3.7 | 2.1–5.3 |
| α2β2γ2L | 12.2 | 10.5–15.8 | 11 | 8.6–13.5 |
| α2β3γ2L | 0.48 | 0.32–0.64 | 7.5 | 5.2–9.9 |
| α2β3 | 3.37 | 2.77–3.97 | 1.98 | 0.67–3.29 |
| α4β3γ2L | 1.82 | 1.02–2.62 | 3.0 | 1.7–4.3 |
| α4β3δ | 2.66 | 1.36–3.96 | ND | ND |
| α6β1γ2L | > 20 | – | ND | ND |
| α6β2γ2L | 20 | 18.3–21.7 | 26.9 | 20.3–33.2 |
| α6β3γ2L | 0.40 | 0.29–0.51 | 5.8 | 4.2–7.4 |
| α6β3γ1 | 6.81 | 3.9–9.7 | ND | ND |
| α6β3δ | 3.69 | 3.18–4.2 | ND | ND |
ND Not determined