Table 1.
Characteristics of the IOW and MAAS (Caucasians only) cohort studies participants.
| Characteristic | IOW cohort % (n/total) |
MAAS cohort % (n/total) |
|---|---|---|
| Sex | ||
| Male | 51.2 (745/1456) | 54.5 (577/1058) |
| Female | 48.8 (711/1456) | 45.5 (481/1058) |
| Allergic sensitization at age | ||
| 4 years | 19.6 (192/982) | — |
| 5 years | — | 29.0 (240/827) |
| 8 years | — | 32.8 (268/818) |
| 10 years | 26.9 (279/1036) | — |
| 11 years | — | 35.2 (256/728) |
| 18 years | 41.4 (353/853) | — |
| IL4R rs3024676 | ||
| AA | 2.3 (26/1149) | 3.3 (30/907) |
| AC | 29.1 (335/1149) | 29.2 (265/907) |
| CC | 68.6 (788/1149) | 67.5 (612/907) |
| MAF (allele A) | 0.17 | 0.18 |
| HWE P value | 0.199 | 0.841 |
| FLG variants | ||
| R501X | 4.1 (47/1161) | 4.6 (40/870) |
| 2282del4 | 4.6 (54/1168) | 4.5 (37/828) |
| S3247X | 1.6 (18/1165) | 0.8 (7/909) |
| FLG haploinsufficiency * | 10.3 (118/1150) | 9.9 (80/809) |
MAF: Minor allele frequency; HWE: Hardy-Weinberg equilibrium.
*Analyses were conducted using the combined carriage of a FLG null allele; that is, if a child carried 1 or more of the FLG variants R501X, 2282del4, or S3247X, he or she was classified as having filaggrin haploinsufficiency.