Table 3.
Association of FLG variants and IL4R rs3024676 with allergic sensitization: results from IOW cohort study.
| Allergic sensitization at age | FLG variants | IL4R rs3024676 genotype | ||
|---|---|---|---|---|
| WT | LOF | AC | AA/CC | |
| 4 years, % (n/total) | 19.6 (147/751) | 27.2 (25/92) | 19.2 (46/240) | 21.3 (129/605) |
| OR (95% CI)* | 1.00 | 1.51 (0.92–2.47) | 1.00 | 1.15 (0.79–1.68) |
| P value | 0.105 | 0.468 | ||
| 10 years, % (n/total) | 26.4 (227/859) | 41.1 (39/95) | 22.2 (63/284) | 30.2 (201/666) |
| OR (95% CI)* | 1.00 | 1.89 (1.22–2.93) | 1.00 | 1.56 (1.12–2.16) |
| P value | 0.004 | 0.008 | ||
| 18 years, % (n/total) | 41.3 (293/709) | 50.6 (43/85) | 38.1 (86/226) | 44.0 (250/568) |
| OR (95% CI)* | 1.00 | 1.41 (0.89–2.23) | 1.00 | 1.32 (0.96–1.81) |
| P value | 0.140 | 0.090 | ||
| Repeated measurements, % (k/total)† | 28.8 (667/2319) | 39.3 (107/272) | 26.0 (195/750) | 31.5 (580/1839) |
| OR (95% CI) | 1.00 | 1.47 (1.01–2.14) | 1.00 | 1.25 (0.97–1.62) |
| P value | 0.046 | 0.085 | ||
FLG WT: FLG wild-type genotype; FLG LOF: FLG loss-of-function genotype; k = number of repeated measurements.
*Association adjusted for sex.
†Association adjusted for sex and age at follow-up.