Table 4.
Association of FLG variants with allergic sensitization stratified by IL4R rs3024676 genotypes: results from IOW cohort study.
| Allergic sensitization at age | IL4R rs3024676 Homozygous (AA/CC) | IL4R rs3024676 Heterozygous (AC) | ||
|---|---|---|---|---|
| FLG WT | FLG LOF | FLG WT | FLG LOF | |
| 4 years, % (n/total) | 20.1 (107/532) | 30.3 (20/66) | 18.3 (39/213) | 21.7 (5/23) |
| OR (95% CI)* | 1.00 | 1.71 (0.97–3.01) | 1.00 | 1.20 (0.42–3.44) |
| P value | 0.064 | 0.738 | ||
| 10 years, % (n/total) | 28.2 (168/595) | 50.0 (31/62) | 22.8 (57/250) | 20.7 (6/29) |
| OR (95% CI)* | 1.00 | 2.55 (1.50–4.35) | 1.00 | 0.86 (0.33–2.23) |
| P value | < 0.001 | 0.762 | ||
| 18 years, % (n/total) | 42.3 (212/501) | 60.7 (37/61) | 40.5 (81/200) | 19.1 (4/21) |
| OR (95% CI)* | 1.00 | 2.07 (1.20–3.59) | 1.00 | 0.32 (0.10–0.99) |
| P value | 0.009 | 0.048 | ||
| Repeated measurements, % (k/total)† | 29.9 (487/1628) | 46.6 (88/189) | 26.7 (177/663) | 20.6 (15/73) |
| OR (95% CI) | 1.00 | 1.97 (1.27–3.05) | 1.00 | 0.53 (0.22–1.32) |
| P value | 0.003 | 0.175 | ||
FLG WT: FLG wild-type genotype; FLG LOF: FLG loss-of-function genotype; k = number of repeated measurements.
*Association adjusted for sex.
†Association adjusted for sex and age at follow-up.