Table 5.
Association of FLG variants and IL4R rs3024676 with allergic sensitization: results from MAAS cohort study
| Allergic sensitization at age | FLG variants | IL4R rs3024676 genotype | ||
|---|---|---|---|---|
| WT | LOF | AC | AA/CC | |
| 5 years, % (n/total) | 28.2 (187/662) | 44.8 (30/67) | 29.8 (67/225) | 28.9 (157/543) |
| OR (95% CI)* | 1.00 | 1.97 (1.18–3.30) | 1.00 | 0.97 (0.69–1.37) |
| P value | 0.010 | 0.871 | ||
| 8 years, % (n/total) | 31.3 (202/646) | 48.6 (36/74) | 35.0 (76/217) | 31.1 (169/543) |
| OR (95% CI)* | 1.00 | 2.05 (1.25–3.35) | 1.00 | 0.84 (0.60–1.18) |
| P value | 0.004 | 0.321 | ||
| 11 years, % (n/total) | 34.8 (202/581) | 43.8 (28/64) | 39.6 (76/192) | 32.5 (159/489) |
| OR (95% CI)* | 1.00 | 1.47 (0.86–2.49) | 1.00 | 0.74 (0.52–1.04) |
| P value | 0.155 | 0.087 | ||
| Repeated measurements, % (k/total)† | 31.3 (591/1889) | 45.9 (94/205) | 34.5 (219/634) | 30.8 (485/1575) |
| OR (95% CI) | 1.00 | 1.73 (1.13–2.63) | 1.00 | 0.87 (0.65–1.15) |
| P value | 0.011 | 0.328 | ||
FLG WT: FLG wild-type genotype; FLG LOF: FLG loss-of-function genotype; k = number of repeated measurements.
*Association adjusted for sex.
†Association adjusted for sex and age at follow-up.