Table 6.
Association of FLG variants with allergic sensitization stratified by IL4R rs3024676 genotypes: results from MAAS cohort study.
| Allergic sensitization at age | IL4R rs3024676 Homozygous (AA/CC) | IL4R rs3024676 Heterozygous (AC) | ||
|---|---|---|---|---|
| FLG WT | FLG LOF | FLG WT | FLG LOF | |
| 5 years, % (n/total) | 28.2 (124/439) | 46.2 (18/39) | 28.6 (52/182) | 42.9 (9/21) |
| OR (95% CI)* | 1.00 | 2.11 (1.08–4.11) | 1.00 | 1.74 (0.68–4.45) |
| P value | 0.028 | 0.249 | ||
| 8 years, % (n/total) | 29.4 (128/436) | 52.2 (24/46) | 33.9 (58/171) | 45.5 (10/22) |
| OR (95% CI)* | 1.00 | 2.58 (1.39–4.81) | 1.00 | 1.60 (0.65–3.94) |
| P value | 0.003 | 0.307 | ||
| 11 years, % (n/total) | 31.8 (125/393) | 45.0 (18/40) | 40.0 (62/155) | 41.2 (7/17) |
| OR (95% CI)* | 1.00 | 1.71 (0.88–3.34) | 1.00 | 1.08 (0.39–2.99) |
| P value | 0.115 | 0.889 | ||
| Repeated measurements, % (k/total)† | 29.7 (377/1268) | 48.0 (60/125) | 33.9 (172/508) | 43.3 (26/60) |
| OR (95% CI) | 1.00 | 1.93 (1.12–3.31) | 1.00 | 1.44 (0.66–3.12) |
| P value | 0.017 | 0.360 | ||
FLG WT: FLG wild-type genotype; FLG LOF: FLG loss-of-function genotype; k = number of repeated measurements.
*Association adjusted for sex.
†Association adjusted for sex and age at follow-up.