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. 2018 Feb 19;8:3249. doi: 10.1038/s41598-018-21405-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of pendrin and ENaC is increased in the kidney of WNK1^+/FHHT:SPAK^243A/243A mice. Upper panel: Representative immunoblots performed with antibodies against the γ subunit of the epithelial channel ENaC and pendrin on the membrane-enriched fractions of the renal cortex of mice of each genotype. FL: Full-length and CL: cleaved form of γENaC, respectively. Lower panel: Densitometric analysis. The abundance and cleavage of γ-ENaC are increased in WNK1^+/FHHT:SPAK^243A/243A mice and SPAK^243A/243A mice. The expression of pendrin increases significantly in WNK1^+/FHHT:SPAK^243A/243A mice. Number of animals: 4 control, 5 WNK1^+/FHHt, 4 WNK1^+/FHHt:SPAK^243A:243A and 4 SPAK^243A:243A male mice. Values are means ± s.e.m. ^ap < 0.05 vs. controls. ^bp < 0.05 vs. WNK1^+/FHHt mice^FHHt (Kruskal-Wallis one-way analysis of variance followed by Mann-Whitney test). Immunoblot images are cropped images. The full-length images can be found in Supplementary Figure S4.