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. 2018 Feb 19;8:3249. doi: 10.1038/s41598-018-21405-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative double immunostainingstaining for total OSR1 (in green) and NCC (in red) in the renal cortex of control, WNK1^+/FHHt, WNK1^+/FHHt:SPAK^243A/243A and SPAK^243A/243A mice. OSR1 colocalize with NCC in distal convoluted tubule cells. Lower panel: quantification of apical OSR1 staining in distal convoluted tubule cells. OSR1 staining is significantly more apical in WNK1^+/FHHt:SPAK^243A:243A and SPAK^243A:243A mice. Number of animals: 4 control, 2 WNK1^+/FHHt, 4 WNK1^+/FHHt:SPAK^243A:243A and 4 SPAK^243A:243A male mice. Values are means ± s.e.m. ^ap < 0.05 vs. controls.